Ezh2 does not mediate retinal ganglion cell homeostasis or their susceptibility to injury.
Epigenetic predisposition is thought to critically contribute to adult-onset disorders, such as retinal neurodegeneration.The histone methyltransferase, enhancer of zeste homolog 2 (Ezh2), is transiently expressed in the perinatal retina, particularly enriched in retinal ganglion cells (RGCs).We previously showed that embryonic deletion of Ezh2 fro